- ￥3256
- Biorbyt
- orb1730583
- 英国
- 2025年07月15日
- ICC, IHC, WB
- Rabbit
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Phospho-GSK3 (Tyr279/Tyr216) Antibody 抗体
- 抗体英文名：
Phospho-GSK3 (Tyr279/Tyr216) Antibody
- 浓度：
详询
- 应用范围：
ICC, IHC, WB
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat
- 保质期：
6-12个月
- 抗原来源：
详询
- 目录编号：
orb1730583
- 级别：
科研
- 库存：
99
- 供应商：
Biorbyt
- 标记物：
Unconjugated
- 克隆性：
POLYCLONAL
- 保存条件：
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- 形态：
详询
- 亚型：
Rabbit IgG
- 免疫原：
Synthetic peptide of human GSK3A
- 规格：
100 ul
GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase.
产品名：Phospho-GSK3 (Tyr279/Tyr216) Antibody
货号：orb1730583
产品中文名：Phospho-GSK3 (Tyr279/Tyr216) Antibody 抗体
产品详情链接：https://www.biorbyt.com/phospho-gsk3-tyr279tyr216-a-orb1730583.html
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文献和实验) is accompanied with or inactivates the GSK activity. However, it is still not conclusive what the role of Tyr phosphorylation (Y216 fro beta, Y279 for alpha) on GSK activity is. One reference is a review paper published in Cell in 2001, you may take a quick
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
loop of the kinase domain (Tyr279 in GSK3a, andTyr216 in GSK3b), which is absolutely required for kinase activity. Thirdly, phosphorylation of GSK3 at a conserved N-terminalserine residue inhibits its kinase activity. This phosphoserine actsas
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
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