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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
Rat IgG2a, κ
- 形态:
液体
- 保存条件:
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
- 克隆性:
FJK-16s
- 标记物:
PE
- 适应物种:
Mouse; Rat
- 保质期:
12个月
- 目录编号:
E-AB-F1351D
- 级别:
科研级别
- 库存:
999
- 供应商:
武汉伊莱瑞特生物科技股份有限公司
- 宿主:
Rat
- 应用范围:
ICFCM
- 抗体英文名:
PE Anti-Mouse/Rat FOXP3 Antibody[FJK-16s]_货号:E-AB-F1351D
- 抗体名:
PE Anti-Mouse/Rat FOXP3 Antibody[FJK-16s]_货号:E-AB-F1351D
- 规格:
100Tests/50Tests/100Tests×2
| 规格: | 100Tests | 产品价格: | ¥3420.0 |
|---|---|---|---|
| 规格: | 50Tests | 产品价格: | ¥1920.0 |
| 规格: | 100Tests×2 | 产品价格: | ¥5100.0 |
货号:E-AB-F1351D
| Background |
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
|
| Alternate Names |
Forkhead box protein P3; Scurfin; JM2; IPEX; Zinc finger protein JM2
|
| Swissprot |
Q99JB6
|
| Gene ID |
20371
|
| Clone No |
FJK-16s
|
| Host |
Rat
|
| Reactivity |
Mouse; Rat
|
| Application |
ICFCM
|
| Isotype |
Rat IgG2a, κ
|
| Isotype Control |
PE Rat IgG2a, κ Isotype Control[2A3]
|
| Conjugation |
PE
|
| Conjugation Information |
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
|
| Spectrum |
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
流式抗体优势
1.多色可选:多达13种荧光标记,适用于更多实验方案,提供免费配色和数据分析服务,提供整体流式解决方案
2.性价比高:提供20 T小包装规格,仅需¥300~500
3.库存充足:常规抗体,现货库存,24 h内发货
4.出口品质:源于经典克隆,第三代无损标记工艺,自有国内最大细胞库,实验验证结果可靠,性能对标国际大牌,分群明显

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文献和实验自2012年第一篇引用文献问世,至2023年8月,Elabscience已协助各地科研工作者发表超15,000篇SCI文献,包括行业顶/级期刊Nature Medicine, Nature, Cell, Signal Transduction and Targeted Therapy, Circulation, Molecular Cancer, Immunity, Advanced Materials等,总影响因子(IF)59472.59,其中IF≥30的文献超30篇,最高影响因子为66.849,发文单位包含北京大学、中国科学技术大学、浙江大学、斯坦福大学、耶鲁大学、柏林夏里特大学等国内外各大高校。
每年引用文献数量持续增长,保持逐年30%+高增长率,可以预见,Elabscience产品将帮助更多科研工作者发表高质量SCI论文。
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率。此外,不管是外周血还是肿瘤浸润部位Foxp3+Treg数目都与乳腺癌病人预后好坏有着高度的相关性。由Foxp3在Treg抑制功能中的核心作用来看,一些肿瘤细胞表达Foxp3似乎可以抑制机体对肿瘤细胞的免疫反应,从而导致肿瘤细胞的免疫逃逸。除了用流式细胞技术检测Foxp3之外,有报道称可以用eBioscience Foxp3抗体对脾脏、乳腺、黑素瘤及其他组织进行免疫组化染色(冰冻切片和石蜡切片)。C57BI/6 小鼠脾脏染色使用anti-mouse/rat Foxp3 抗体(克隆号:FJK-16s)标记C57
可能与其他物种发生交叉反应, 除非特异性的经过交叉反应物种的吸附处理。在抗体描述中,经过其他物种的吸附处理的抗体标有“ (min X …Sr Prot) ”字样 。 Anti-IgG (H+L) 这类抗体和 IgG 分子的重链和轻链都可以反应,比如,和 IgG 分子的 Fc , F(ab ’)2/Fab 部分。 Anti-IgG (H+L) 抗体也可以和其他的免疫球蛋白家族( IgM , IgA ,IgD,IgE )和亚家族反应,因为所有的免疫球蛋白都有相同的轻链(或者 κ 链
Immunofluorescent Staining of Mouse and Rat Leukocytes
-up, please see description in "Procedure for Setting Compensation for Multi-Color Flow Cytometric Analysis". For reducing FcgII/IIIR-mediated antibody binding (or binding of SAv-PE or SAv-Cy-Chrome) which could contribute to background, the use of anti-mouse CD32/CD
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