重组人CD134蛋白|OX40

产品编号：KMP2302

产品名称：Human CD134 Protein, Fc Tag, Avi Tag

中文名称： 重组人CD134蛋白

中文全称：重组人肿瘤坏死因子受体超家族成员4蛋白

产品描述：产品描述：The Human CD134 Protein(KMP2302) is produced in HEK293 Cells and the target gene encoding Leu29-Ala216 is expressed with a Fc, Avi tag at the C-terminus.

产品别称：肿瘤坏死因子受体超家族成员4, Tumor necrosis factor receptor superfamily member 4, CD134

分子名称：CD134

预测分子量：20.16 kDa

物种：Human

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:P23510

功能：Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

产品背景：OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand(OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.