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- 2025年12月05日
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货期：询盘
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- CAS号：
2758431-90-0
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10 mg/25 mg
| 规格： | 10 mg | 产品价格： | ￥2664.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥5336.0 |
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Thalidomide 4'-ether-PEG2-azide
CAS No. : 2758431-90-0
MCE 国际站：Thalidomide 4'-ether-PEG2-azide
产品活性：Thalidomide 4'-ether-PEG2-azide 是通过点击化学修饰的、cereblon (CRBN) 抑制剂 Thalidomide (HY-14658)。Thalidomide 4'-ether-PEG2-azide 含有叠氮基，可以与含有炔基的分子进行铜催化的叠氮-炔环加成反应 (CuAAc)。Thalidomide 4'-ether-PEG2-azide 可作为 E3 泛素连接酶的配体和 Linker 的偶联物 (E3 Ligase Ligand-Linker Conjugates)，用于 PROTACs 。
研究领域：PROTAC
作用靶点：E3 Ligase Ligand-Linker Conjugates
相关产品：VH285-PEG4-C4-Cl | (S,R,S)-AHPC-PEG2-N3 | (S,R,S)-AHPC-PEG5-COOH | VH032-PEG5-C6-Cl | (S,R,S)-AHPC-PEG3-N3 | (S,R,S)-AHPC-PEG4-N3 | Lenalidomide-C5-NH2 hydrochloride | N-Descyclopropanecarbaldehyde Olaparib | Pomalidomide-PEG2-COOH | (S,R,S)-AHPC-PEG1-N3 | (S,R,S)-AHPC-PEG2-NH2 hydrochloride | Cbl-b-IN-2 | Pomalidomide-PEG1-C2-N3 | Pomalidomide 4'-PEG5-acid | Thalidomide-O-PEG4-NHS ester | Pomalidomide 4'-alkylC5-acid | Pomalidomide 4'-PEG2-azide | Pomalidomide-PEG4-azide | VH032-PEG3-acetylene | (S,R,S)-AHPC-amido-C5-acid | (S,R,S)-AHPC-PEG2-C4-Cl | (S,R,S)-AHPC-PEG3-NH2 hydrochloride | Pomalidomide-C2-NH2 hydrochloride | Pomalidomide-PEG3-azide | Pomalidomide-PEG4-C-COOH | Thalidomide-4-O-C6-NH2 hydrochloride | (S,R,S)-AHPC-PEG4-NH2 | Lenalidomide-propargyl-C2-NH2 hydrochloride | Pomalidomide-PEG1-C2-COOH | Thalidomide-O-PEG2-propargyl
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文献和实验The Thalidomide Disaster, Lessons from the Past
It is close to 60 years since thalidomide was created by the German company, Chemie-Gr�nenthal, and launched as “Contergan.” This was soon to be followed in England by the launch of “Distaval.” Of all the drugs developed in the intervening
哺乳类缺少四肢或部分肢脚的一种畸形。完全缺乏者亦称为无肢畸形（amelia）。自然发生者相当罕见。酞胺哌啶酮（ thalidomide）具有明显的引起这种畸形的作用。
In Vivo Animal Models of Teratogenicity
Before the advent of the thalidomide tragedy, it had often been assumed that the maternal biosystems of hepatic detoxification and metabolism, together with the placental barrier, acted as a shield and were a natural protection for the embryo
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