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文献和实验Leukocyte-Endothelial Monolayer Adhesion Assay (Static Conditions)
-receptor pairing of a series of adhesion molecule expressed by both circulating leukocytes and the endothelial cell (1 ). The sequential and coordinated interaction of these leukocyte-endothelial adhesion molecules, in conjunction with the localized
Construction and Purification of Adhesion Molecule Immunoglobulin Chimeric Proteins
for a given cell-surface molecule. Particularly useful in this respect have been soluble forms of proteins created by fusing the extracellular domains of the protein of interest to the Fc part of an antibody molecule (1 ). The resulting dimeric proteins
(TNF-α), as well as other pro- and antiin-flammatory cytokines are also present in the RA ST. These soluble mediators have an effect on leukocyte activation, upregulation of cell adhesion receptors on lining cells and endothelial cells, tissue
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