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Human IL-21 (2ug)
种属
Human
已发表种属
Dog, Human, Mouse, Non-human primate, Rhesus monkey
Expression System表达系统
E. coli
氨基酸序列
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
预测分子量
15.4 kDa
分类
Recombinant
类型
Protein
纯度
≥ 98% by SDS-PAGE gel and HPLC analyses.
内毒素浓度
<1 EU/µg
活性
Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x10^6 units/mg.
偶联物
Unconjugated
形式
Lyophilized
Amount
10 µg
纯化类型
purified
成分
no preservative
保存条件
-20°C
运输条件
Ambient
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文献和实验[1]Tsai DY, Wang CH, Schiro PG, Chen N, Tseng JY. Tracking B Cell Memory to SARS-CoV-2 Using Rare Cell Analysis System. Vaccines (Basel). 2023;11(4):735. Published 2023 Mar 26. doi:10.3390/vaccines11040735
[2]Shiqi L, Jiasi Z, Lvzhe C, et al. Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T. Mol Ther Oncolytics. 2023;29:107-117. Published 2023 Apr 20. doi:10.1016/j.omto.2023.04.003
[3]Shiqi L, Jiasi Z, Lvzhe C, et al. Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T. Mol Ther Oncolytics. 2023;29:107-117. Published 2023 Apr 20. doi:10.1016/j.omto.2023.04.003
[4]Lee DY, Kim Y, Park JS, Choi JU, Jeong HG, Park CH. Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion. Anticancer Res. 2023;43(9):3897-3904. doi:10.21873/anticanres.16577
[5]Fichtner ML, Hoehn KB, Ford EE, et al. Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Acta Neuropathol Commun. 2022;10(1):154. Published 2022 Oct 28. doi:10.1186/s40478-022-01454-0
[6]Schneider MM, Emmenegger M, Xu CK, et al. Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma. Life Sci Alliance. 2021;5(2):e202101270. Published 2021 Nov 30. doi:10.26508/lsa.202101270
[7]Niehues H, Rikken G, van Vlijmen-Willems IMJJ, et al. Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis. JID Innov. 2021;2(1):100066. Published 2021 Oct 22. doi:10.1016/j.xjidi.2021.100066
[8]Manolakou T, Nikolopoulos D, Gkikas D, et al. ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus. Sci Adv. 2022;8(43):eabo5840. doi:10.1126/sciadv.abo5840
[9]Sokal A, Chappert P, Barba-Spaeth G, et al. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response. Cell. 2021;184(5):1201-1213.e14. doi:10.1016/j.cell.2021.01.050
[10]Dejnirattisai W, Zhou D, Ginn HM, et al. The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell. 2021;184(8):2183-2200.e22. doi:10.1016/j.cell.2021.02.032
[11]Sokal A, Barba-Spaeth G, Fernández I, et al. mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants. Immunity. 2021;54(12):2893-2907.e5. doi:10.1016/j.immuni.2021.09.011
[12]Almeida L, Dhillon-LaBrooy A, Castro CN, et al. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity. 2021;54(1):68-83.e6. doi:10.1016/j.immuni.2020.11.001
[13]Ehx G, Larouche JD, Durette C, et al. Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes. Immunity. 2021;54(4):737-752.e10. doi:10.1016/j.immuni.2021.03.001
[14]Yao Y, Chen Z, Zhang H, et al. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021;22(9):1127-1139. doi:10.1038/s41590-021-00996-0
[15]Vlahava VM, Murrell I, Zhuang L, et al. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. J Clin Invest. 2021;131(4):e139296. doi:10.1172/JCI139296
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