] LiuZJ,RanYY,QieSY,etal.Melatoninprotectsagainstischemic strokebymodulatingmicroglia/macrophagepolarizationtowardanti-in-flammatoryphenotypethroughSTAT3pathway[J].CNSNeurosciTher,2019,25(12):1353-1362.driven not only by the accumulation of intrinsic alterations in malignant cells, but also by the interactions of cancer cells with various stromal cell components of the tumor microenvironment. In particular, inflammation and infiltration of the tumor tissue by host immune cells, such as