HUANGWK,WU CE,WANGSY,etal.Systemictherapyforgas-trointestinalstromaltumor:Currentstandardsandemergingchallen-ges[J].CurrTreatOptionsOncol,2022,23(9):1303-1319. that some highly immunogenic cell lines displayed a bimodal distribution consisting of H60a-hi and H60a-lo cells. In one of these cell lines, the H60a-hi cells could be removed by passaging the cells through RAG2(-/-) mice, resulting in edited cell lines that were poor targets for NK cells and