H19controlsDUSP5/ERK1/2axisincardiac fibroblastproliferationandfibrosis[J]. CardiovascPathol, 2016,25(5):381⁃389.production. Single-cell transcriptomic profiling and flow cytometry analysis mapped the tumor microenvironment of Prkar1a mutant tumors and revealed the transcriptomic alterations in host myeloid cells. Taken together, our data suggest that tumor-intrinsic mutations in Prkar1a lead to drastic alterations in the genetic program of cancer cells, thereby remodeling the tumor