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- 文献和实验
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- 英文名：
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- 库存：
现货库存
- 供应商：
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- 肿瘤类型：
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- 细胞类型：
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- 品系：
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- 组织来源：
ATCC/DSMZ/ECACC
- 相关疾病：
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- 物种来源：
人或动物
- 免疫类型：
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- 细胞形态：
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- 是否是肿瘤细胞：
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- 器官来源：
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- 运输方式：
常温或干冰
- 年限：
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- 生长状态：
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| 种属 | 小鼠 |
| 别称 | 4T1+OVA |
| 组织来源 | 乳腺 |
| 疾病 | 乳腺癌 |
| 传代比例/细胞消化 | 1:2传代 ，消化3-4分钟 |
| 完全培养基配置 | RPMI1640培养基；10%胎牛血清；1%双抗 |
| 简介 | 4T1是从410.4瘤株中未经诱变筛得的6-硫鸟嘌噙抗性细胞株。当注射到BALB/c小鼠中时 ，4T1自发产生高转移肿 瘤 ，可转移到肺 ，肝 ，淋巴结和大脑 ，同时在注射部位形成始发灶。诱导转移时不需要摘除始发灶。4T1细胞BALB/c 小鼠中的生长与转移特性与人体中的乳腺癌十分相近。这种肿瘤是人VI期乳腺癌的动物模型。4T1-诱导的肿瘤在手术 后及未手术情况下转移的动力学相近 ，可以用作手术后及未手术模型。跟其他肿瘤模型相比 ，由于4T1的抗6- 硫鸟嘌 噙特性 ，微小的转移细胞团(少到仅仅1个)也可以在许多远端器官中检测到。没必要数淋巴结或称重器官。 |
| 形态 | 上皮细胞样 |
| 生长特征 | 贴壁生长 |
enhance antigen presentation. It is also important to define which patients will respond to therapy with ICIs as over half of all patients sukler from immune-related adverse events (irAE), solk of which are severe and long-lasting.lktastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the
more comprehensive and in vivo-like immune oncology model that can be utilized for high-throughput study of tumoricidal activity.Purpose/objective(s): Bulky tumors remain challenging to be treated. Stereotactic body radiation therapy (SBRT) is effective against radioresistant tumor cells and can induce immunogenic cell death (ICD) that leads to
human bone metastases when compared to a human normal epithelial cell line. All the analyzed genes were overexpressed in the tumor cells of breast cancer bone metastases when compared to normal breast tissue. We did not detect any differences between the expression of these genes in bone metastases from breast cancer or from other types of solid tumors. Importantly, there was a significant correlation between the expressions of IL11/CTGF, IL11/ADAMTS1, CTGF/CXCR4, CTGF/ADAMTS1, and MMP-1/ADAMTS1, supporting the cooperative function of these proteins in the bone microenvironment, and the potential functional role of these genes in the establishment of bone metastases in vivo.
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文献和实验enhance antigen presentation. It is also important to define which patients will respond to therapy with ICIs as over half of all patients sukler from immune-related adverse events (irAE), solk of which are severe and long-lasting.lktastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the
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