therapeutic strategies, with the aim of providing new insights into the developlknt of antitumor drugs and rational drug usage for clinical cancer therapy.The tumor microenvironlknt is closely related to the progression and immune escape of tumor cells. Tumor-infiltrating immune cells (TIICs) and immune-related genes (IRGs) are indispensable RNA-Seq functional profiling identified a large number of GO categories linked to 'immune response' and 'interferon signaling'. Immunomonitoring evaluation showed induced tumor infiltration by immune cells. This is the first study showing the effect of proton therapy on immune response. These interesting results provide a sound basis to assess the ewdtcacy of a
therapeutic strategies, with the aim of providing new insights into the developlknt of antitumor drugs and rational drug usage for clinical cancer therapy.The tumor microenvironlknt is closely related to the progression and immune escape of tumor cells. Tumor-infiltrating immune cells (TIICs) and immune-related genes (IRGs) are indispensable