HLA-DO/B Polyclonal Antibody_货

Verified Samples in IHC:Human tonsil

IHC 1:40-1:200, ELISA 1:5000-1:10000

Polyclonal

IgG

Synthetic peptide of human HLA-DO/B

HLA-DO/B

HLA-DO/B;HLA class II histocompatibility antigen;DO beta chain;MHC class II antigen DO/B抗体

P13765

Endosome membrane,Lysosome,lysosomal membrane,lysosome,Plasma Membrane,MHC class II protein complex,Other locations:integral component of membrane

1.26 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen aF/FInity purification

Immunology

Unconjugated

HLA-DO/B belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DO/B), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DO/B (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.