FOXO1 多克隆抗体

Western Blot（WB）已验证样本:Mouse liver,Mouse kidney,Mouse brain,Rat liver,Rat kidney

WB 1:500-1:2000

Polyclonal

IgG

Recombinant protein corresponding to Mouse FOXO1

FOXO1

FKH 1;FKH1;FKHR;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead box O1;Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead;Drosophila;homolog of;in rhabdomyosarcoma;FoxO transcription factor;foxo1;FOXO1;FOXO1A;OTTHUMP00000018301抗体

Q9R1E0,G3V7R4

78-82kDa

78kDa

Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus.

0.58 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling; Metabolism; Neuroscience; Signal Transduction

Unconjugated

FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).