FAS Polyclonal Antibody 货号：E-A

Verified Samples in IHC: Human appendix, Mouse Immunized spleen, Mouse Immunized thymus

IHC 1:200-1:800

Polyclonal

IgG

Recombinant protein corresponding to Mouse FasL

FAS

ALPS 1A, ALPS1A, APO 1, APO 1 cell surface antigen, APO1, APO1 cell surface antigen, APT 1, APT1, Apo 1 antigen, Apo-1 antigen, Apo1 antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, CD 95, CD 95 antigen, CD95

P25445, P25446, Q63199

Cell membrane, Membrane, Secreted.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH 7.4.

Affinity purification

Cancer, Cell Biology, Immunology

Unconjugated

FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.