MRE11 多克隆抗体

免疫组织化学（IHC）已验证样本:Human thyroid cancer,Human breast cancer

IHC 1:100-1:300

Polyclonal

IgG

Recombinant protein of human MRE11A

MRE11A

AT like disease;Ataxia telangiectasia disorder like;ATLD;DNA recombination and repair protein;Double strand break repair protein MRE11A;Double-strand break repair protein MRE11A;endo/exonuclease Mre11;HNGS1;meiotic recombination (S. cerevisiae) 11 homolog A;Meiotic recombination 11 homolog 1;meiotic recombination 11 homolog A (S. cerevisiae);Meiotic recombination 11 homolog A;MmMRE11A;Mre 11;MRE 11a;MRE 11b;MRE11 homolog 1;MRE11 homolog A;MRE11 homolog double strand break repair nuclease;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11 meiotic recombination 11 homolog A;MRE11;MRE11A;MRE11b;OTTHUMP00000236830;OTTHUMP00000236831;OTTHUMP00000236832;OTTHUMP00000236833抗体

P49959

Nucleus. Localizes to discrete nuclear foci after treatment with genotoxic agents.

0.5 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling

Unconjugated

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.