7β-Hydroxy-epi-androsterone,25

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7β-Hydroxy-epi-androsterone

CAS No. : 25848-69-5

MCE 国际站：7β-Hydroxy-epi-androsterone

产品活性：7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) 可以与 ERβ 结合并具有抗炎和神经保护特性。7β-Hydroxy-epi-androsterone 是 dehydroepiandrosterone 的内源性雄激素衍生物。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Estrogen Receptor/ERR

In Vitro: 7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 72 h) inhibits MCF-7 and MDA-MB-231 cell proliferation in the presence of E2 (10 nM).
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) leads to a G0/G1 cell cycle arrest in MCF-7 and MDA-MB-231 cells.
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 48 h) increases cell apoptosis in the presence of E2 (10 nM) in MCF-7 cells.
7β-Hydroxy-epi-androsterone (1, 10 and 100 nM, 24 h) binds to ERβ and decreases in transactivation in MDA-MB-231 cells.

In Vivo: 7β-Hydroxy-epi-androsterone (i.p., once a day for 7 days) displays anti-inflammatory effects in rat with DSS-induced colitis.
7β-Hydroxy-epi-androsterone (0.1 mg/kg s.c., b.i.d. for 10 days) shows protective effect against inflammatory neurodegeneration and glial cell death in Alzheimer's disease rats.

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