γ-Secretase modulator 14,14202

又一种代糖被证明有健康风险！Nature：大量摄入会抑制机体免疫，却被认为能治疗疾病？

健康，但人们还不完全了解三氯蔗糖对身体的影响，也对食用某些甜味剂的长期安全性提出了担忧。   2023 年 3 月 15 日，来自英国弗朗西斯克里克研究所等单位的研究团队在 Nature 发表了题为 The dietary sweetener sucralose is a negative modulator of T cell-mediated responses 的文章，在本研究中，他们发现，小鼠摄入高剂量的三氯蔗糖可通过限制 T 细胞增殖和 T 细胞分化而产生免疫调节的作用。在皮下肿瘤模型和细菌感染模型中

「体温低」竟能更长寿！Nature Aging 研究揭示低温延寿的关键机制

. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nature Aging (2022). 2. Zhao, Z. J. et al. Body temperature is a more important modulator of lifespan than metabolic rate

Quantifying Allosteric Modulation of G Protein-Coupled Receptors

of the modulator (K 2 ) and the product (γ ) of the modulatory changes in the observed affinity and efficacy of the agonist-receptor complex (γ  =  a  β ). In many instances, it is impossible through analysis of receptor function only to determine