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- 2025年12月05日
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货期：询盘
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MedChemExpress LLC
- CAS号：
2860554-32-9
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询盘
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Sigma-2 Radioligand 1
CAS No. : 2860554-32-9
MCE 国际站：Sigma-2 Radioligand 1
产品活性：Sigma-2 Radioligand 1 (compound 1) 是 Sigma-2 选择性配体。Sigma-2 Radioligand 1 在小鼠中具有良好生物分布性，在大鼠中具有良好体内活性。[18F] 修饰的 Sigma-2 Radioligand 1，在微型 PET/CT 成像中将肿瘤可视化，呈现高肿瘤摄取和肿瘤背景比。实验表明，Sigma-2 Radioligand 1 在 U87MG 胶质瘤异种移植物中具有高特异性结合。
研究领域：Neuronal Signaling
作用靶点：Sigma Receptor
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文献和实验Saturation Assays of Radioligand Binding to Receptors and Their Allosteric Modulatory Sites
. Radioligand binding (in this case, 5 nM [3 H](+)‐pentazocine binding to the sigma receptor in guinea‐pig brain) increases exponentially with time, becoming maximal after 60 min. Based on this data, equilibrium binding assays employing this radioligand
Radioligand Binding Assays for the Glycine Site on N‐Methyl‐D‐Aspartate Receptors
for nonspecific binding determination at 10× final concentration: 1 mM (10×) glycine (prepare fresh) or 30 µM (10×) MDL‐105,519 (Sigma), store in aliquots up to 6 months at –40°C 10× Radioligand: 40
and then centrifuge at 14,000 RPM for 3 minutes. Save 20µl of the elutes as (Flag-Input). Next, take the remaining ~80µl of elute to clean tubes containing 40µl of EZVIEW™ Red anti-Flag M2 affinity gel beads (Sigma™) which have been pre-treated with a wash in 250µl
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