Lynestrenol利奈孕醇,52-76-6

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Lynestrenol

CAS No. : 52-76-6

MCE 国际站：Lynestrenol

产品活性：Lynestrenol 是一种孕烷 X 受体 (PXR) 激动剂，对 hPXR 和 zfPXR 的 EC₅₀ 值分别为 41 和 0.23 µM。Lynestrenol 是一种合成的孕酮类化合物，具有免疫刺激特性。

研究领域：Others

作用靶点：Others

In Vitro: Lynestrenol markedly enhances the lymphocyte response to phytohemagglutinin, the mixed lymphocyte culture, the active T-rosette test, the autologous red cell rosettes, and the number of nonadherent cells in the leukocyte adherence inhibition test. Lynestrenol also increases monocyte phagocytosis. Lynestrenol delays the appearance of malignant tumors in hamsters.

In Vivo: Lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells. Lynestrenol is studied at three different doses (6.87, 13.75 and 27.50 mg/kg). Sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) increase significantly as compared to normal control when treated with Lynestrenol at 13.75 and 27.50 mg/kg.

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