Mitazalimab米佐利单抗米佐利单抗,2055640-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Mitazalimab

CAS No. : 2055640-86-1

MCE 国际站：Mitazalimab

产品活性：Mitazalimab (ADC-1013; JNJ-64457107) 是 FcγR 依赖性 CD40 激动剂，具有肿瘤导向活性。Mitazalimab 激活抗原呈递细胞，例如 树突状细胞 (DC)，以启动肿瘤反应性 T 细胞。因此，Mitazalimab 诱导肿瘤特异性 T 细胞浸润并杀死肿瘤。Mitazalimab 可重塑肿瘤浸润性骨髓微环境。

研究领域：Apoptosis

作用靶点：TNF Receptor

In Vitro: Mitazalimab (1 ng/mL-10 μg/mL) activates tumor associated macrophages (TAMs) in prostate tumor or ovarian tumor samples from human.

In Vivo: Mitazalimab (100 μg/mouse; i.p.; single dose) activates splenic DC and B cells in Naïve hCD40tg mice, and also results expansion of OVA-specifc CD8+ T cells in OVA-rechallenged (200 μg; i.v.; 3 times for 7 days between) mice.
Mitazalimab (100 and 300 μg/mouse, i.p.; on day 7, 10 and 13 post-inoculation) induces the release of proinfammatory cytokines and chemokines in the blood in MB49 (mouse bladder tumor cell line) bearing mice, and alters the composition of tumor myeloid cells, such that reduces monocytes and macrophages in favor of granulocytic cell.

相关产品：Resatorvid  |  Shikonin  |  Infliximab  |  Fisetin  |  Adalimumab  |  Etanercept  |  N-Formyl-Met-Leu-Phe  |  QNZ  |  Theophylline  |  R-7050  |  Apremilast  |  C25-140  |  UCB-9260  |  Diprovocim  |  Muscone  |  Brentuximab vedotin  |  TRAF-STOP inhibitor 6877002  |  Certolizumab pegol  |  Astilbin  |  Forsythoside B  |  Geraniin  |  Semapimod tetrahydrochloride  |  Sinensetin  |  HS-276  |  DRI-C21045  |  Belimumab  |  Mulberroside A  |  Adalimumab (anti-TNF-α)  |  Tryptanthrin  |  SPD304

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds