H-2Db 抗体 [28-14-8]-H-2Db Antib

H-2Db 抗体 [28-14-8]，H-2Db Antibody [28-14-8]，H-2Db 抗体 [28-14-8],H-2Db Antibody [28-14-8]

产品名称：H-2Db 抗体 [28-14-8]-H-2Db Antibody [28-14-8]

产品货号：PSI-99-070-0.5mg

产品规格：0.5mg

背景资料：The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 28-14-8 binds to the alpha3 domain of H-2Db in the presence or absence of beta2 microglobulin. It cross reacts with the alpha3 domain of H-2Ld, but not Kd or Dd, and with H-2Dq and/or Lq. The antibody has been shown to block H-2Ld-specific and H-2Ld-restricted antigen-specific lysis of target cells by cytotoxic T lymphocytes but it does not block recognition of H-2Ld-positive target cells by Ly-6G2-positive NK cells.

保存建议：H-2Db 抗体 [28-14-8]-H-2Db Antibody [28-14-8]Store vial at 2-8℃

应用类型：IHC-Fr, ICC, Flow, IP

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