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- 文献和实验
- 技术资料
- 免疫原:
HP1γ (phospho Ser93) antibody was raised against a peptide sequence around phosphorylation site of Serine 93 (R-L-S (p)-L-S) derived from Human HP1γ .
- 保存条件:
Store antibody at -20℃ for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
HP1γ (phospho Ser93) Antibody
- 抗体名:
HP1γ (phospho Ser93) Antibody
- 规格:
0.1mg
HP1γ (phospho Ser93) 抗体,HP1γ (phospho Ser93) Antibody,HP1γ (phospho Ser93) 抗体,HP1γ (phospho Ser93) Antibody
产品名称:HP1γ (phospho Ser93) 抗体-HP1γ (phospho Ser93) Antibody
产品货号:PSI-79-879-0.1mg
产品规格:0.1mg
背景资料:At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
保存建议:HP1γ (phospho Ser93) 抗体-HP1γ (phospho Ser93) AntibodyStore antibody at -20℃ for up to one year
应用类型:WB
点击:HP1γ (phospho Ser93) 抗体-HP1γ (phospho Ser93) Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验机制,并证实出生后早期基因治疗可显著逆转疾病表型。研究团队构建的Csnk2b杂合突变小鼠-完-美模拟了患者核心症状,表现为社交障碍、焦虑、记忆损伤、自发性癫痫及生存率下降;机制上,突变导致皮层变薄、PV阳性中间神经元发育异常及皮层兴奋-抑制失衡,γ波段功率异常升高且长程网络同步性受损。采用AAV-PHP.eB载体进行全脑CSNK2B基因替换治疗后,小鼠生存率提升至80%,癫痫发生率由70%降至10%-20%,并显著挽救行为异常。该研究还首次建立了可转化的EEG生物标志物体系,为CSNK2B相关神经发育疾病
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
Optimized Protocol to Make Phospho-Specific Antibodies that Work
, not simply its level of expression. In this review, we will discuss both the design of the phosphopeptide immunogen and immunization. The affinity purification of the phospho-specific antibody as well as the methods most suitable for characterizing
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