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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant full-length human protein was used as the immunogen for the CD79a antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
Flow, IF, IHC-P
- 抗体英文名:
CD79a Antibody [CDLA79a-1]
- 抗体名:
CD79a Antibody [CDLA79a-1]
- 规格:
100ug
CD79a 抗体 [CDLA79a-1],CD79a Antibody [CDLA79a-1],CD79a 抗体 [CDLA79a-1],CD79a Antibody [CDLA79a-1]
产品名称:CD79a 抗体 [CDLA79a-1]-CD79a Antibody [CDLA79a-1]
产品货号:PSI-33-901-100ug
产品规格:100ug
背景资料:A disulphide-linked heterodimer consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, CD79 is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with RituximAb (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.
保存建议:CD79a 抗体 [CDLA79a-1]-CD79a Antibody [CDLA79a-1]Aliquot and Store at 2-8℃
应用类型:Flow, IF, IHC-P
点击:CD79a 抗体 [CDLA79a-1]-CD79a Antibody [CDLA79a-1]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验CD79a/CD79b 分子 CD79a 常用单克隆抗体或代号: Iga ,mb- 1 主要表达细胞: B [B] 分子质量(kDa)和结构: 33(IgSF) 功 能: BCR复合体组成成分 CD79b 常用单克隆抗体或代号: Igb ,B29 主要表达细胞: B [B] 分子质量(kDa)和结构: 39(IgSF) 功 能: BCR复合体组成成分
区各有一个ITAM,为信号转导所必需。 (二)Iga/Igp分子 Igα(CD79a)和Igβ(CD79b)以二聚体形式存在。两条肽链可分为胞外区、跨膜区和胞质区。从图可以看出,Igα和Igβ链的胞质区特别长,其中Ige为61个氨基酸残基,Igp为48个氨基酸残基,各有一个ITAM,为信号转导所必需。
CD79 α/ CD79 β 白细胞分化抗原及其功能 Igα/Igβ 又称CD79α/CD79β,胞膜外区结构属IgSF,分别有1个C2样区和V样结构域,跨膜区都有一个谷氨酸。两个CD79a/CD79b异二聚体与一个mlg构成B细胞抗原识别受体(BCR)。CD79a和CD79b跨膜区带负电的谷氨酸或谷氨酰胺与mlgM重链跨膜区带正电的氨基酸可形成盐桥,稳定BCR复合物。两种CD79分子的胞质区均有一个ITAM,介导由BCR途径的信号转导。该类CD
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