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- ProSci
- 美国
- PSI-33-659-100ug
- 2025年07月11日
- Flow, IHC, IF, WB
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
- 保存条件：
Aliquot and Store at 2-8℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
Flow, IHC, IF, WB
- 抗体英文名：
FOXA1 Antibody [FOXA1/1512]
- 抗体名：
FOXA1 Antibody [FOXA1/1512]
- 规格：
100ug
FOXA1 抗体 [FOXA1/1512]，FOXA1 Antibody [FOXA1/1512]，FOXA1 抗体 [FOXA1/1512],FOXA1 Antibody [FOXA1/1512]
产品名称：FOXA1 抗体 [FOXA1/1512]-FOXA1 Antibody [FOXA1/1512]
产品货号：PSI-33-659-100ug
产品规格：100ug
背景资料：FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
FOXA1 in breast cancer is highly correlated with ERalpha+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERalpha+ breast cancer, and its expression might identify ERalpha+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERalpha− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERalpha− cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment. [Wiki]
保存建议：FOXA1 抗体 [FOXA1/1512]-FOXA1 Antibody [FOXA1/1512]Aliquot and Store at 2-8℃
应用类型：Flow, IHC, IF, WB
点击：FOXA1 抗体 [FOXA1/1512]-FOXA1 Antibody [FOXA1/1512]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验Using MACS to Identify Peaks from ChIP‐Seq Data
Lupien, M., Eeckhoute, J., Meyer, C.A., Wang, Q., Zhang, Y., Li, W., Carroll, J.S., Liu, X.S., and Brown, M. 2008. FoxA1 translates epigenetic signatures into enhancer driven lineage‐specific transcription. Cell 132:958‐970
质数量及其重复数目，决定用于抗原-抗体相互作用研究的芯片点样模式。那些能用荧光检测分辨出来的点的最大点样密度主要依赖于点样方法和芯片扫描仪的分辨率。当我们采用我们自己的点样方法，分辨率为 10 μm 的扫描仪，点样模式为 14 X 14 ( 点间距为 321 μm ) 或 15 X 15 ( 点间距是 300 μm) 时 ，我们可获得足以判定荧光信号的分辨率（数据未显示）。至今我们还没有实验更大的点样模式。Lueking 和他的同事[ 15 ] 成功地使用 PAA 片基，用相同的点样方法，成功地以 13 X
A Detailed Protocol for Formaldehyde‐Assisted Isolation of Regulatory Elements (FAIRE)
Eeckhoute, J., Lupien, M., Meyer, C., Verzi, M., Shivdasani, R., Liu, X.S., and Brown, M. 2009. Cell‐type selective chromatin remodeling defines the active subset of FOXA1‐bound enhancers. Genome Res. 19:372‐380
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