Cytochrome C 抗体 [6H2.B4]-Cytoc

Cytochrome C 抗体 [6H2.B4]，Cytochrome C Antibody [6H2.B4]，Cytochrome C 抗体 [6H2.B4],Cytochrome C Antibody [6H2.B4]

产品名称：Cytochrome C 抗体 [6H2.B4]-Cytochrome C Antibody [6H2.B4]

产品货号：PSI-33-454-100ug

产品规格：100ug

背景资料：Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

保存建议：Cytochrome C 抗体 [6H2.B4]-Cytochrome C Antibody [6H2.B4]Aliquot and Store at 2-8℃

应用类型：WB, IP, Flow, IF

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