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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p27 KIP 1 (NP_004055.1).
- 保存条件:
Store at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB,IHC,IF
- 抗体英文名:
p27 KIP 1 Antibody
- 抗体名:
p27 KIP 1 Antibody
- 规格:
50uL
p27 KIP 1 抗体,p27 KIP 1 Antibody,p27 KIP 1 抗体,p27 KIP 1 Antibody
产品名称:p27 KIP 1 抗体-p27 KIP 1 Antibody
产品货号:PSI-16-151-50uL
产品规格:50uL
背景资料:This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
保存建议:p27 KIP 1 抗体-p27 KIP 1 AntibodyStore at -20℃
应用类型:WB,IHC,IF
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文献和实验-induced responses, including a down-regulation of the cyclin-dependent kinase (Cdk2) inhibitors p21CIP1 and p27KIP1 , while attachment to P-L-L did not. We conclude that engagement of the FN-receptor integrin α5β1 induces integrin signaling regulating
for determining the activity of PNAs designed to target oncomiRNAs, using as model system miR-221 and its target p27Kip1 mRNA. The effects of PNAs targeting miR-221 are here presented discussing data obtained using as model system the human breast cancer cell line
The Regulation of Tumor Suppressor Genes by Oncogenes
-1/WAF1/mda6 (p21), p27 Kip-1 (p27), p16 INK4a (p16), and p19 ARF (p19), play the role of negative regulators of the cell cycle (1 –5 ). In contrast, mutation of protooncogenes such as the epidermal growth factor receptor (EGFR) (6 ), ErbB2 (Neu
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