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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic peptide corresponding to a sequence within amino acids 130-230 of human MDM2 (NP_002383.2).
- 保存条件:
Store at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB,IHC,IF
- 抗体英文名:
MDM2 Antibody
- 抗体名:
MDM2 Antibody
- 规格:
50uL
MDM2 抗体,MDM2 Antibody,MDM2 抗体,MDM2 Antibody
产品名称:MDM2 抗体-MDM2 Antibody
产品货号:PSI-13-148-50uL
产品规格:50uL
背景资料:This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
保存建议:MDM2 抗体-MDM2 AntibodyStore at -20℃
应用类型:WB,IHC,IF
点击:MDM2 抗体-MDM2 Antibody查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验CELL杂志04年11月份的一篇paper,介绍了单个SNP的功能学研究的方法。 点击下面链接下载 A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans.pdf
小红赛 我目前在做药物靶向治疗肿瘤的课题,想在肿瘤细胞水平上以P53—MDM2为靶点,研究阻断MDM2或阻止P53水解时的信号变化及对细胞生长的影响,但目前不知道在P53—MDM2这个靶点上,有什么好的药物或者抑制剂,能用于细胞水平研究的,谢谢 selleckchem01 在这个靶点 下面两个抑制剂都可以用于细胞试验~ Nutlin-3 Nutlin-3 is a MDM
Antisense Oligonucleotide Inhibitors of MDM2 Oncogene Expression
Antisense therapy represents a novel genetic-based therapeutic approach, initiated by Zamecnik et al. about 20 years ago (1 ). The rationale for antisense oligonucleotide therapeutics is straightforward: to identify a specific inhibitor
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