CD40 抗体-CD40 Antibody

CD40 抗体，CD40 Antibody，CD40 抗体,CD40 Antibody

产品名称：CD40 抗体-CD40 Antibody

产品货号：PSI-13-083-50uL

产品规格：50uL

背景资料：This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

保存建议：CD40 抗体-CD40 AntibodyStore at -20℃

应用类型：WB,IHC,IF

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