BRCA1 抗体-BRCA1 Antibody

BRCA1 抗体，BRCA1 Antibody，BRCA1 抗体,BRCA1 Antibody

产品名称：BRCA1 抗体-BRCA1 Antibody

产品货号：PSI-13-081-50uL

产品规格：50uL

背景资料：This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

保存建议：BRCA1 抗体-BRCA1 AntibodyStore at -20℃

应用类型：WB,IHC,IF

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