TIM-3 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM-3.<br>The immunogen is located within amino acids 60 - 110 of TIM-3.
保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
背景资料:The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM-3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).
保存建议:TIM-3 抗体-TIM-3 Antibody stored at 4℃ for three months and -20℃, stable for up to one year