TIM-3 抗体-TIM-3 Antibody

TIM-3 抗体，TIM-3 Antibody，TIM-3 抗体,TIM-3 Antibody

产品名称：TIM-3 抗体-TIM-3 Antibody

产品货号：PSI-8659-0.02mg

产品规格：0.02mg

背景资料：The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM-3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

保存建议：TIM-3 抗体-TIM-3 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB, IHC-P, IF

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