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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
RAP80 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RAP80.<br>The immunogen is located within amino acids 520 - 570 of RAP80.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
E, WB, IHC-P, IF
- 抗体英文名:
RAP80 Antibody
- 抗体名:
RAP80 Antibody
- 规格:
0.02mg
RAP80 抗体,RAP80 Antibody,RAP80 抗体,RAP80 Antibody
产品名称:RAP80 抗体-RAP80 Antibody
产品货号:PSI-4325-0.02mg
产品规格:0.02mg
背景资料:RAP80 Antibody: RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
保存建议:RAP80 抗体-RAP80 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB, IHC-P, IF
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