ARF-BP1 抗体-ARF-BP1 Antibody

ARF-BP1 抗体，ARF-BP1 Antibody，ARF-BP1 抗体,ARF-BP1 Antibody

产品名称：ARF-BP1 抗体-ARF-BP1 Antibody

产品货号：PSI-4213-0.02mg

产品规格：0.02mg

背景资料：ARF-BP1 Antibody: The ARF tumor suppressor is a critical regulator of p53 stability. In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs. ARF-BP1 directly binds and ubiquitinates p53; this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF. ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis. Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.

保存建议：ARF-BP1 抗体-ARF-BP1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB, ICC, IF

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