Caspase-12 抗体 (Large)-Caspase-

Caspase-12 抗体 (Large)，Caspase-12 Antibody (Large)，Caspase-12 抗体 (Large),Caspase-12 Antibody (Large)

产品名称：Caspase-12 抗体 (Large)-Caspase-12 Antibody (Large)

产品货号：PSI-3195-0.02mg

产品规格：0.02mg

背景资料：Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

保存建议：Caspase-12 抗体 (Large)-Caspase-12 Antibody (Large) stored at -20℃, stable for one year

应用类型：E, WB, IHC-P, IF

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