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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD279 (PD-1)
- 级别：
CD279 (PD-1) Antibody
- 目录编号：
CD279 (PD-1) Antibody
- 克隆性：
单克隆
- 抗原来源：
大鼠
- 保质期：
CD279 (PD-1) Antibody
- 抗体英文名：
Fire™ 750 anti-mouse CD279 (PD-1) Antibody-APC
- 抗体名：
CD279 (PD-1) Antibody
- 标记物：
APC
- 宿主：
大鼠
- 适应物种：
小鼠
- 免疫原：
CD279 (PD-1) Antibody
- 亚型：
CD279 (PD-1) Antibody
- 形态：
CD279 (PD-1) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
25 µg/ 100 µg
| 规格： | 25 µg | 产品价格： | ￥2400.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥6100.0 |
Fire™ 750 anti-mouse CD279 (PD-1) Antibody-APC详细如下：
Description ：CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging tothe CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells andthymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyteclonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positiveselection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation isessential for prolonged survival of intratesticular islet allografts.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：PD-1 cDNA followed by PD-1-Ig fusion protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 underoptimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm
Description ：CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging tothe CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells andthymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyteclonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positiveselection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation isessential for prolonged survival of intratesticular islet allografts.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：PD-1 cDNA followed by PD-1-Ig fusion protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 underoptimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Good-Jacobson KL, et al. 2010. Nat. Immunol. 11:535. (FC) PubMed
2. Lázár-Molnár E, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2658. (Block)
3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706. (FC, IHC, Block)
4. Tobias J, et al. 2020. Front Immunol. 11:895 (FC, ELISA) PubMed
5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations：
1. Levesque S, et al. 2019. Oncoimmunology. 8:e1657375. PubMed
2. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
3. Abdelsamed HA, et al. 2020. Nat Immunol. 1.276388889. PubMed
4. Tomaru U et al. 2019. Cell reports. 26(3):639-651 . PubMed
1. Good-Jacobson KL, et al. 2010. Nat. Immunol. 11:535. (FC) PubMed
2. Lázár-Molnár E, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2658. (Block)
3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706. (FC, IHC, Block)
4. Tobias J, et al. 2020. Front Immunol. 11:895 (FC, ELISA) PubMed
5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations：
1. Levesque S, et al. 2019. Oncoimmunology. 8:e1657375. PubMed
2. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
3. Abdelsamed HA, et al. 2020. Nat Immunol. 1.276388889. PubMed
4. Tomaru U et al. 2019. Cell reports. 26(3):639-651 . PubMed
文献支持
Fire™ 750 抗小鼠 CD279 (PD-1) 荧光标记APC 抗体
￥2400 - 6100
