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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD279 (PD-1)
- 级别:
CD279 (PD-1) Antibody
- 目录编号:
CD279 (PD-1) Antibody
- 克隆性:
单克隆
- 抗原来源:
大鼠
- 保质期:
CD279 (PD-1) Antibody
- 抗体英文名:
anti-mouse CD279 (PD-1) Antibody-APC
- 抗体名:
CD279 (PD-1) Antibody
- 标记物:
APC
- 宿主:
大鼠
- 适应物种:
小鼠
- 免疫原:
CD279 (PD-1) Antibody
- 亚型:
CD279 (PD-1) Antibody
- 形态:
CD279 (PD-1) Antibody
- 应用范围:
FC
- 保存条件:
2-8℃
- 浓度:
0.2 mg/ml
- 规格:
25 µg/ 100 µg
| 规格: | 25 µg | 产品价格: | ¥1900.0 |
|---|---|---|---|
| 规格: | 100 µg | 产品价格: | ¥5000.0 |
Description :CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging tothe CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells andthymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyteclonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positiveselection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation isessential for prolonged survival of intratesticular islet allografts.
Verified Reactivity :Mouse
Antibody Type :Monoclonal
Host Species :Rat
Immunogen :PD-1 cDNA followed by PD-1-Ig fusion protein
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography, and conjugated with APC under optimalconditions.
Concentration :0.2 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application :FC - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser :Red Laser (633 nm)
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文献和实验1. Good-Jacobson KL, et al. 2010. Nat. Immunol. 11:535. (FC) PubMed
2. Lázár-Molnár E, et al. 2008. Proc. Natl. Acad. Sci. USA 105:2658. (Block)
3. Liang SC, et al. 2003. Eur. J. Immunol. 33:2706. (FC, IHC, Block)
4. Tobias J, et al. 2020. Front Immunol. 11:895 (FC, ELISA) PubMed
5. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
6. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations:
1. Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed
2. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
3. Xie A et al. 2017. Endocrinology. 158(10):3140-3151 . PubMed
4. Zhou J, et al. 2019. Immunity. 50:403. PubMed
5. Qi Z, et al. 2022. Nat Commun. 13:182. PubMed
6. Wu Q, et al. 2021. Cancer Commun (Lond). Online ahead of prin. PubMed
7. Lino AC et al. 2018. Immunity. 49(1):120-133 . PubMed
8. Wang J, et al. 2019. Front Immunol. 9:3157. PubMed
9. Liu QZ, et al. 2018. Front Immunol. 1.131944444. PubMed
10. Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed
11. Smith T, et al. 2014. J Immunol. 193:3409. PubMed
12. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
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