Dazzle™ 594 抗人 CD274 (B7-H1, P

Dazzle™ 594 anti-human CD274 (B7-H1, PD-L1) Antibody-PE详细如下：

Description ：CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves asa ligand for CD279 (PD-1). This interaction is believed to regulate the balance between thestimulatory and inhibitory signals needed for responses to microbes and maintenance of selftolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γproduction in an IL-2-dependent and CD279-independent manner. Conflicting data has shownthat CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhanceT cell activation. Other studies suggest that CD274 may signal bidirectionally, raisinginteresting implications for its expression in a wide variety of cell types, including T and B cells,antigen-presenting cells, and nonhematopoietic cells.

Verified Reactivity ：Human

Reported Reactivity ：African Green, Baboon, Cynomolgus, Rhesus

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Full length human PD-L1

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 underoptimal conditions.

Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：FC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.

* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.

Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)