- ￥3300 - 7700
- 齐源
- 137231
- 国产/进口
- 2025年07月07日
- ICFC
- 亚美尼亚仓鼠
- 人、小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
Helios
- 级别：
Helios Antibody
- 目录编号：
Helios Antibody
- 克隆性：
单克隆
- 抗原来源：
亚美尼亚仓鼠
- 保质期：
Helios Antibody
- 抗体英文名：
Dazzle™ 594 anti-mouse/human Helios Antibody/PE
- 抗体名：
Helios Antibody
- 标记物：
PE
- 宿主：
亚美尼亚仓鼠
- 适应物种：
人、小鼠
- 免疫原：
Helios Antibody
- 亚型：
Helios Antibody
- 形态：
Helios Antibody
- 应用范围：
ICFC
- 保存条件：
2-8℃
- 浓度：
Helios Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3300.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥7700.0 |
Description ：Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a Cterminal region composed of 2 zinc-finger domains that mediate dimerization between thefamily members. Helios was originally cloned from a mouse thymoma line. It is mainlyexpressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation ofregulatory T cells. Helios plays an important role in T cell development and homeostasis.Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has beendetermined that silencing of Helios in B cells is critical for maintaining normal B cell function.Helios is also involved in tumor immunity.
Verified Reactivity ：Mouse, Human
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Immunogen ：Helios peptide (aa 51-107)
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 underoptimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：ICFC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by intracellular flow cytometry using our TrueNuclear™ Transcription Factor Staining Protocol. For flow cytometric staining, the suggested useof this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验1. Thornton AM, et al. 2010. J. Immunol. 184:1. PubMed
2. Verhagen J and Wraith D. 2010. J. Immunol. 185:7129.
3. Stone B, et al. 2012. Clin Immunol. 145:153. PubMed
4. Vaeth M, et al. 2012. PNAS. 109:16258. PubMed
5. Angin M, et al. 2014. PLoS One. 9:86920. PubMed
6. Bedke T, et al. 2014. Immunol Cell Biol. PubMed
7. Liu Y, et al. 2014. Am J Physiol Gastrointest Liver Physiol. 307:177. PubMed
8. Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
Product Citations：
1. Martens PJ, et al. 2022. Front Endocrinol (Lausanne). 13:1023264. PubMed
2. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
3. Bergamaschi L, et al. 2021. Immunity. 54(6):1257-1275.e8. PubMed
4. Becker W, et al. 2021. J Crohns Colitis. 15:1032. PubMed
抗体二抗上连接有荧光染料。直接标记染色背景低，实验程序少尽量减少实验工序和过程，以保证实验的真实和准确性。因此在条件允许的范围内，建议尽量用直接标记的抗体进行实验。 3、流式抗体荧光标记的选择： 如果实验中检测单一指标：不同荧光标记在不同的仪器上强度不同。以某仪器为例：PE ＞APC ＞PE-Cy5 ＞PerCP ＞FITC ＞PerCP-Cy5.5，通常来说，PE最强，适用于弱表达抗原。FITC强度较弱，适用于强表达抗原，使用范围比较广。用户需根据检测的目标蛋白进行具体选择。 如果同时检测多个
地高辛抗体大全―原装进口酶标及各种荧光标记抗地高辛抗体 地高辛（Digoxin）是一种从洋地黄提取出的beta抑制剂性的药物，被广泛用于治疗高血压、瓣膜性心脏病、先天性心脏病等急性和慢性心功能不全的一种药物。由于地高辛的治疗指数狭窄，用药过量与用药不足时的症状相似，加之其个体差异大，故中毒的发生率高，是临床上最难掌握药物之一。目前解除地高辛毒性的最有效的方法是应用地高辛抗体。此外，采用抗地高辛抗体 的免疫分析法监测血清/血浆地高辛浓度已成为当今治疗性药物监测的典范
, Rhodamine Red等568nm处红色荧光染料。 CF 568染料耐光性最好；高效水溶性；比Alexa Fluor 568 标记的抗体亮度更亮。 CF 594、Alexa Fluor® 594, ATTO™ 594, DyLight™ 594, Texas Red 等最亮红色荧光染料。 CF594由于其高量子产量和优异的水溶性而比AlexaFluor594 明亮2~4倍。同时CF594 对光极其稳定，使它能被理想地应用于诸如共聚焦显微镜和单分子显像条件苛刻的应用中去。 5、远红外
