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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
TCR Vγ1.1/Cr4
- 级别：
TCR Vγ1.1/Cr4 Antibody
- 目录编号：
TCR Vγ1.1/Cr4 Antibody
- 克隆性：
单克隆
- 抗原来源：
亚美尼亚仓鼠
- 保质期：
TCR Vγ1.1/Cr4 Antibody
- 抗体英文名：
Cyanine5.5 anti-mouse TCR Vγ1.1/Cr4 Antibody/PerCP
- 抗体名：
TCR Vγ1.1/Cr4 Antibody
- 标记物：
PerCP
- 宿主：
亚美尼亚仓鼠
- 适应物种：
小鼠
- 免疫原：
TCR Vγ1.1/Cr4 Antibody
- 亚型：
TCR Vγ1.1/Cr4 Antibody
- 形态：
TCR Vγ1.1/Cr4 Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
25 ug/100 ug
| 规格： | 25 ug | 产品价格： | ￥2700.0 |
|---|---|---|---|
| 规格： | 100 ug | 产品价格： | ￥6000.0 |
Description ：T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δchain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays akey role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garmannomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almostexclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a majorpopulation of γ/δ T cells in the thymus and peripheral lymphoid organs in adult mice, but theyare only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1T cell development can happen in thymus-dependent and thymus-independent manners.Further studies have shown that the antibody 2.11 recognizes an epitope located in the Cr4domain.
Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the variousnomenclature systems, we have created charts for corresponding names across some of themost popular naming methods. Click here to see charts.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Immunogen ：T3.13.1 T-cell hybridoma cell line
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5under optimal conditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is = 0.25 µg per millioncells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance foreach application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
Excitation Laser ：Blue Laser (488 nm)
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文献和实验1. Pereira P, et al. 1995. J. Exp. Med. 182:1921. (IP)
2. Pereira P and Boucontet L. 2004. J. Immunol. 173:3261. (FC)
3. Pereira P, et al. 1996. Intl. Immunol. 8:83. (FC)
Product Citations：
1. Harsha Krovi S, et al. 2020. Nat Commun. 4.790277778. PubMed
分子。 表1-2 CD分子的主要特征 CD 常用单克隆抗体或代号（ ） 主要表达细胞 分子量（kDa)和结构 功能 CDla T6,Leu6 Thy,DC,LHC gp49 TCRγδ的配体？ CDlb WM-25,4A76,NUT2 Thy,LHC gp45 TCRγδ的配体？ CDlc L161,M241,7C6 Thy,DC,Bsub gp43 TCRγδ的配体？ CD2 9.6,T11,Leu5; (LFA-2,SRBC-R) T,NKsub. gp
1 - 1 7p15 识别MHC/多肽复合物 TCRδ链 40～60 1 - 1 14q11.2 识别MHC/多肽复合物 TCRγ链 25～28 - 1 - 11q23 TCR信号传导 TCRδ链 20 - 1 - 11q23 TCR信号传导 TCRε链 20 - 1 - 11q23 TCR信号传导 续表1 成 员 分子量 （kDa) Ig结构域类型 人染色体 定 位 主要功能 C1 C2 V MHC抗原及相关分子 MHCⅠ类抗原α链 44
半胱氨酸之间含65～75个氨基酸残基，有9个反平行β折叠股，如IgH链和L链V区，TCRα、β、γ、δ链V区，CD4v区，CD8α、β链V区，Thy-1,pIgR和分泌成分（SC）N端四个功能区，CEAN端第一个功能区，PDGFR靠近胞膜的功能区等。 （2）C1组：又称C组。C1组功能区二个半胱氨酸之间约含50～60个氨基酸残基，有7个β折叠股，如IgH链和L链C区（γ、δ和α链的CH1～CH3或μ和ε链的CH1～CH4），TCRα、β、γ、δ链C区，MHc Ⅰ类分子重链α3功能区，β2
