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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
TIGIT (Vstm3)
- 级别：
TIGIT (Vstm3) Antibody
- 目录编号：
TIGIT (Vstm3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
TIGIT (Vstm3) Antibody
- 抗体英文名：
anti-mouse TIGIT (Vstm3) Antibody-PE
- 抗体名：
TIGIT (Vstm3) Antibody
- 标记物：
PE
- 宿主：
小鼠
- 适应物种：
小鼠
- 免疫原：
TIGIT (Vstm3) Antibody
- 亚型：
TIGIT (Vstm3) Antibody
- 形态：
TIGIT (Vstm3) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
25 ug/100 ug
| 规格： | 25 ug | 产品价格： | ￥2300.0 |
|---|---|---|---|
| 规格： | 100 ug | 产品价格： | ￥5700.0 |
anti-mouse TIGIT (Vstm3) Antibody-PE详细如下：
Description ：T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set andtransmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane proteinand member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper,memory, and regulatory T cells as well as on NK cells. Its binding partners include CD155(PVR) and CD112 (PVRL2). TIGIT is a negative regulator of NK and T cell activation.Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenicphenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Micedeficient for TIGIT are more susceptible to autoimmune disease.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Mouse
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
Description ：T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set andtransmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane proteinand member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper,memory, and regulatory T cells as well as on NK cells. Its binding partners include CD155(PVR) and CD112 (PVRL2). TIGIT is a negative regulator of NK and T cell activation.Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenicphenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Micedeficient for TIGIT are more susceptible to autoimmune disease.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Mouse
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Joller N, et al. 2010. J. Immunol. 186:1338.
Product Citations：
1. Chan S, et al. 2022. Nat Cancer. . PubMed
2. Wang L, et al. 2019. Cell Rep. 29:1848. PubMed
3. Liu X, et al. 2020. Nature. . PubMed
4. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
5. Yasuda K, et al. 2019. Nat Commun. 10:549. PubMed
6. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
7. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
8. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
9. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
10. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
11. Zuo S, et al. 2021. EBioMedicine. 64:103240. PubMed
1. Joller N, et al. 2010. J. Immunol. 186:1338.
Product Citations：
1. Chan S, et al. 2022. Nat Cancer. . PubMed
2. Wang L, et al. 2019. Cell Rep. 29:1848. PubMed
3. Liu X, et al. 2020. Nature. . PubMed
4. Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
5. Yasuda K, et al. 2019. Nat Commun. 10:549. PubMed
6. Wu J, et al. 2020. Sci Adv. 6:eaba3458. PubMed
7. Kawakami R, et al. 2021. Immunity. 54(5):947-961.e8. PubMed
8. Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed
9. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
10. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
11. Zuo S, et al. 2021. EBioMedicine. 64:103240. PubMed
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抗小鼠 TIGIT (Vstm3) 荧光标记PE 抗体
￥2300 - 5700
