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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
erbB3/HER-3
- 级别：
erbB3/HER-3 Antibody
- 目录编号：
erbB3/HER-3 Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
erbB3/HER-3 Antibody
- 抗体英文名：
Purified anti-human erbB3/HER-3 Antibody
- 抗体名：
erbB3/HER-3 Antibody
- 标记物：
erbB3/HER-3 Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
erbB3/HER-3 Antibody
- 亚型：
erbB3/HER-3 Antibody
- 形态：
erbB3/HER-3 Antibody
- 应用范围：
FC, ICC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
100 µg
Description ：The 1B4C3 monclonal antibody recognizes human erbB3/HER3 also know as oncogene erbB3,tyrosine kinase cell surface receptor HER3, and C-erbB3. erbB3/HER3 is a receptor tyrosinekinase and a member of the epidermal growth factor receptor family. erbB3/HER3 binds theheregulin ligands and contains 4 furin-like repeats, 2 cheY receiver domains, and a tyrosinekinase domain with a predicted molecular weight approximately 148 kD. Signaling through theerbB3/HER3 receptor induces proliferation and differentiation in some cell types, the receptoris widely expressed in many tissues including kidney, lung, brain, placenta, skin and stomach.erbB3/HER3 forms constitutively active heterodimers with erbB2/HER2 in a subset of humanmammary tumors; expression of erbB3/HER3 reported be linked to favorable outcome inbladder and ovarian cancer. erbB3/HER3 has been shown to interact with a number of proteinsincluding EGF receptor, erbB2/HER2, erbB4, Grb2, Grb7, SOS1, cdk5, SHC, FAK, PTK6, andothers. The erb3/HER3 receptor is extensively phosphorylated at residues T873 and S1123(by cdk5); Y1199, Y1262, Y1289, and Y1328. The 1B4C3 antibody has been shown to beuseful for flow cytometric detection of human erbB3/HER3.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：NIH-3T3 cells transfected with human erbB3/HER3
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested、ICC - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per millioncells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance foreach application.
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文献和实验1. Jenke R, et al. 2020. Int J Mol Sci. 22:. PubMed
2. Hutt M, et al. 2018. Oncotarget. 9:11322. PubMed
3. Rau A, et al. 2021. MAbs. 1902034:13. PubMed
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