相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
CD269 (BCMA)
- 级别:
CD269 (BCMA) Antibody
- 目录编号:
CD269 (BCMA) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD269 (BCMA) Antibody
- 抗体英文名:
TotalSeq™-B0056 anti-human CD269 (BCMA) Antibody
- 抗体名:
CD269 (BCMA) Antibody
- 标记物:
CD269 (BCMA) Antibody
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
CD269 (BCMA) Antibody
- 亚型:
CD269 (BCMA) Antibody
- 形态:
CD269 (BCMA) Antibody
- 应用范围:
PG
- 保存条件:
2-8℃
- 浓度:
0.5 mg/mL
- 规格:
10 µg
Description :CD269, also known as B cell maturation antigen (BCMA), is a 27 kD, single passtransmembrane protein with one TNFR-Cys repeat on its extracellular domain. CD269 is a Bcell maturation factor, essential for the long-term survival of plasma cells. It is expressed byplasmablasts, plasma cells, and germinal center B cells. The ligands of CD269 are BAFF andAPRIL, and its cytoplasmic domain binds several of the TRAF family members.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :BCMA-mouse IgG Fc fusion protein
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 1 mM EDTA
Preparation :The antibody was purified by chromatography and conjugated with TotalSeq™-B oligomer underoptimal conditions.
Concentration :0.5 mg/mL
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application :PG - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis and the oligomer sequence is confirmed by sequencing. TotalSeq™-B antibodies arecompatible with 10x Genomics Single Cell Gene Expression Solutions.
To maximize performance, it is strongly recommended that the reagent be titrated for eachapplication, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2- 8°C for 10 minutes. Carefully pipette out the liquid avoiding the bottom of the tube and add to thecell suspension. For Proteogenomics analysis, the suggested starting amount of this reagent fortitration is ≤ 1.0 µg per million cells in 100 µL volume. Refer to the corresponding TotalSeq™protocol for specific staining instructions.
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验临床验证。抗人CD20(Rituximab)是第1个为FDA批准可用于临床癌症治疗的单抗。Rituximab与细胞表面的CD20分子结合后,可通过诱导ADCC和CDC清除高表达CD20分子的恶性B细胞,从而被认为在低分化的B细胞淋巴瘤和非霍奇金淋巴瘤的治疗中起重要作用。 近年来,另一个备受人们关注的治疗性单抗是抗Her-2的抗体。Her-2是表皮生长因子受体(EGFR)成员,参与乳腺癌的发生,且与乳腺癌患者的预后有关。相应单抗与Her-2结合可阻止Her-2与相应的生长因子的结合,抑制乳腺
水平。结论嵌合抗CD20抗体片段Fab’能抑制Raji细胞生长和诱导细胞凋亡,其作用机制与bcl-2蛋白表达的下降有关。【关键词】抗CD20抗体 B淋巴瘤 Bcl-2【中图分类号】R318 R733CD20对B淋巴细胞的分化增殖具有调节作用[ 1 ] 。CD20是治疗B淋巴细胞瘤的理想靶点。CD20在前B细胞及成熟B细胞中有表达,而浆细胞、造血干细胞及T细胞则无CD20的表达;CD20比较暴露不为其它表面分子所掩盖,易与抗体结合;CD20和抗CD20抗体结合后不发生内吞作用,因而细胞表面CD20数量并不
于骨髓中的记忆性B细胞能以抗原非依赖方式产生长寿性浆细胞,由后者分泌特异性的抗体。上文提到,抗天花疫苗的特异性抗体可存在60余年,如何解释?近来发现,胸腺微环境可提供浆细胞长期存活的信号,包括基质细胞、IL-6和迟现抗原VLA- 4,另外还有IL-5、TNF-a、SDF-1、CD44和BCMA等参与,以及转录因子Aiolos等发挥作用。在胸腺微环境中,骨髓浆细胞高表达抗凋亡分子Bcl-2、A20和IAP-2。记忆性B细胞和浆细胞的产生 记忆性B细胞以抗原非特异











