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- 齐源
- 146102
- 国产/进口
- 2025年07月07日
- FC, WB
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- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CLEC-2 (CLEC1B)
- 级别：
CLEC-2 (CLEC1B) Antibody
- 目录编号：
CLEC-2 (CLEC1B) Antibody
- 克隆性：
单克隆
- 抗原来源：
大鼠
- 保质期：
CLEC-2 (CLEC1B) Antibody
- 抗体英文名：
Purified anti-mouse CLEC-2 (CLEC1B) Antibody
- 抗体名：
CLEC-2 (CLEC1B) Antibody
- 标记物：
CLEC-2 (CLEC1B) Antibody
- 宿主：
大鼠
- 适应物种：
小鼠
- 免疫原：
CLEC-2 (CLEC1B) Antibody
- 亚型：
CLEC-2 (CLEC1B) Antibody
- 形态：
CLEC-2 (CLEC1B) Antibody
- 应用范围：
FC, WB
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
100 µg
Purified anti-mouse CLEC-2 (CLEC1B) Antibody详细如下：
Description ：CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a singlecytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif(hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at alower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells,and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxinrhodocytin; podoplanin has also been identified as an endogenous ligand for CLEC-2.Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif andSyk-dependent platelet activation. CLEC-2 also functions as an activation receptor onmonoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：RBL-2H3 cells stably expressing HA-tagged mouse CLEC2.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested、WB - Reported in the literature, not verified in house
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Description ：CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a singlecytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif(hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at alower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells,and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxinrhodocytin; podoplanin has also been identified as an endogenous ligand for CLEC-2.Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif andSyk-dependent platelet activation. CLEC-2 also functions as an activation receptor onmonoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：RBL-2H3 cells stably expressing HA-tagged mouse CLEC2.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.
Application ：FC - Quality tested、WB - Reported in the literature, not verified in house
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Mourpo-Sß D, et al. 2011. Eur. J. Immunol. 41:3040. (WB)
Product Citations：
1. Bergsma A, et al. 2019. Bone Rep. 10:100196. PubMed
1. Mourpo-Sß D, et al. 2011. Eur. J. Immunol. 41:3040. (WB)
Product Citations：
1. Bergsma A, et al. 2019. Bone Rep. 10:100196. PubMed
相关实验
表达。平足蛋白上的血小板凝集因子会和血小板上的C型外源凝集素CLEC-2结合引起血小板凝集，诱发癌细胞进行血行转移6）。为了验证抑制血小板凝集素是否能抑制癌细胞转移，加藤等人进行了抑制人血小板凝集的抗人平足蛋白抗体的建立实验，实验中得到的抗体就是NZ-17）。NZ-1是以人平足蛋白N末端的14个氨基酸残基（EGGVAMPGAEDDVV）对应的合成肽作为抗原建立的，所以NZ-1对人细胞上的平足蛋白有很高的亲和性，而且能够十分有效地抑制人平足蛋白和CLEC-2的结合，有很大可能能够成为抗体
文献支持
Purified 抗小鼠 CLEC-2 (CLEC1B) 抗体
￥4000
