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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CLEC-2 (CLEC1B)
- 级别：
CLEC-2 (CLEC1B) Antibody
- 目录编号：
CLEC-2 (CLEC1B) Antibody
- 克隆性：
单克隆
- 抗原来源：
大鼠
- 保质期：
CLEC-2 (CLEC1B) Antibody
- 抗体英文名：
anti-mouse CLEC-2 (CLEC1B) Antibody-PE
- 抗体名：
CLEC-2 (CLEC1B) Antibody
- 标记物：
PE
- 宿主：
大鼠
- 适应物种：
小鼠
- 免疫原：
CLEC-2 (CLEC1B) Antibody
- 亚型：
CLEC-2 (CLEC1B) Antibody
- 形态：
CLEC-2 (CLEC1B) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.2 mg/ml
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥2500.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥5500.0 |
anti-mouse CLEC-2 (CLEC1B) Antibody-PE详细如下：
Description ：CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a singlecytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif(hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at alower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells,and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxinrhodocytin; podoplanin has also been identified as an endogenous ligand for CLEC-2.Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif andSyk-dependent platelet activation. CLEC-2 also functions as an activation receptor onmonoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：RBL-2H3 cells stably expressing HA-tagged mouse CLEC2.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
Description ：CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a singlecytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif(hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at alower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells,and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxinrhodocytin; podoplanin has also been identified as an endogenous ligand for CLEC-2.Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif andSyk-dependent platelet activation. CLEC-2 also functions as an activation receptor onmonoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Rat
Immunogen ：RBL-2H3 cells stably expressing HA-tagged mouse CLEC2.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.
Concentration ：0.2 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Mourpo-Sß D, et al. 2011. Eur. J. Immunol. 41:3040. (WB)
Product Citations：
1. Daemen S, et al. 2021. Cell Reports. 34(2):108626. PubMed
2. Nording H, et al. 2021. Nat Commun. 12:3352. PubMed
3. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
4. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
5. Daemen S, et al. 2021. STAR Protoc. 2:100511. PubMed
6. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
1. Mourpo-Sß D, et al. 2011. Eur. J. Immunol. 41:3040. (WB)
Product Citations：
1. Daemen S, et al. 2021. Cell Reports. 34(2):108626. PubMed
2. Nording H, et al. 2021. Nat Commun. 12:3352. PubMed
3. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
4. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
5. Daemen S, et al. 2021. STAR Protoc. 2:100511. PubMed
6. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
文献支持
抗小鼠 CLEC-2 (CLEC1B) 荧光标记PE 抗体
￥2500 - 5500
