抗人 CD360 (IL-21R) 荧光标记PE 抗体

anti-human CD360 (IL-21R) Antibody-PE详细如下：

Description ：Human interleukin 21 receptor (IL-21R) is a single pass type I membrane protein and amember of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibitsgreatest extracellular homology to the IL-2R beta subunit (i.e., it contains one copy of theWSXWS-containing cytokine-binding domain). Intracellular domains of IL-21R include the Box 1and Box 2 elements, which are similar to the IL-9R intracellular region. Upon binding IL-21, IL21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Statsignaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is apotent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly theinflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immuneresponses. These actions include positive effects such as enhanced proliferation of naturalkiller (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells anddirect inhibitory effects on the antigen-presenting function of dendritic cells, and can beproapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrinecytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, andserves as a target for treating inflammatory diseases.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Human IL-21R expressing mouse M1-T22 cell line.

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.

Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：FC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)