Description :The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucinezipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA.C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational startcodons. The C/EBPα p30 isoform has little to no transactivating activity and acts as aninhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required formyeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, sinceinhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycleprogression through interactions with cyclin-dependent kinases (CDK) and by inducing theexpression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with thedevelopment of acute myeloid leukemia.
Verified Reactivity :Human
Reported Reactivity :Mouse
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Synthetic peptide (AKQLALAGLFPYQPPPP) conjugated to KLH.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/mL
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :WB - Quality tested、ICC - Verified
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.1 - 0.5 µg per mL. It is recommended that the reagent be titratedfor optimal performance for each application.