Purified 抗 C/EBPα 抗体

Purified anti-C/EBPα Antibody详细如下：

Description ：The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucinezipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA.C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational startcodons. The C/EBPα p30 isoform has little to no transactivating activity and acts as aninhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required formyeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, sinceinhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycleprogression through interactions with cyclin-dependent kinases (CDK) and by inducing theexpression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with thedevelopment of acute myeloid leukemia.

Verified Reactivity ：Human

Reported Reactivity ：Mouse

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Synthetic peptide (AKQLALAGLFPYQPPPP) conjugated to KLH.

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation ：The antibody was purified by affinity chromatography.

Concentration ：0.5 mg/mL

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C.

Application ：WB - Quality tested、ICC - Verified

Recommended Usage ：Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.1 - 0.5 µg per mL. It is recommended that the reagent be titratedfor optimal performance for each application.