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- 2025年07月13日
- FC, IHC-F
- 仓鼠
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD80
- 级别：
CD80 Antibody
- 目录编号：
CD80 Antibody
- 克隆性：
单克隆
- 抗原来源：
仓鼠
- 保质期：
CD80 Antibody
- 抗体英文名：
Alexa Fluor® 647 anti-mouse CD80 Antibody
- 抗体名：
CD80 Antibody
- 标记物：
CD80 Antibody
- 宿主：
仓鼠
- 适应物种：
小鼠
- 免疫原：
CD80 Antibody
- 亚型：
CD80 Antibody
- 形态：
CD80 Antibody
- 应用范围：
FC, IHC-F
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
25 µg/100 µg
| 规格： | 25 µg | 产品价格： | ￥1700.0 |
|---|---|---|---|
| 规格： | 100 µg | 产品价格： | ￥3900.0 |
Description ：CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is alsoknown as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells andmonocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation ofCD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendriticcells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cellactivation, proliferation, and cytokine production. CD80 appears to be expressed later in theimmune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliveran inhibitory signal to T cells.
Verified Reactivity ：Mouse
Reported Reactivity ：Dog
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Immunogen ：CHO cell line transfected with mouse B7 (CD80)
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation ：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647under optimal conditions.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：FC - Quality tested、IHC-F - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per millioncells in 100 µl volume. For immunohistochemistry on frozen tissue sections, a concentration rangeof 2.5 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimalperformance for each application
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Excitation Laser ：Red Laser (633 nm)
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文献和实验1. Harlan DM, et al. 1994. P. Natl. Acad. Sci. USA 91:3137. (IHC)
2. Razi-Wolf Z, et al. 1992. P. Natl. Acad. Sci. USA 89:4210. (Block, IP)
3. Hathcock KS, et al. 1994. J. Exp. Med. 180:631. (Block)
4. Herold KC, et al. 1997. J. Immunol. 158:984. (Block, IHC)
5. Ma XT, et al. 2006. Cancer Res. 66:1169.
6. Andoniou CE, et al. 2005. Nature Immunology 6:1011. (FC)
7. Lawson BR, et al. 2007. J. Immunol. 178:5366.
8. Turnquist HR, et al. 2007. J. Immunol. 178:7018.
9. Misra RS, et al. 2010. J. Exp Med. 207:1775. PubMed
10. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
11. Philipsen L, et al. 2013. Mol Cell Proteomics. 12:2551. PubMed
Product Citations：
1. Mathur R, et al. 2019. Mucosal Immunol. 12:612. PubMed
2. Lauterbach MA, et al. 2020. Immunity. 51(6):997-1011.e7.. PubMed
3. Hu HJ, et al. 2020. Cell Death Dis. 1.168055556. PubMed
4. Boccasavia VL, et al. 2021. Cell Reports. 34(11):108861. PubMed
5. Shan M et al. 2018. Immunity. 49(4):709-724 . PubMed
6. Jiang Y, et al. 2020. Adv Mater. 32:e2001808. PubMed
7. Misra R, et al. 2010. J Exp Med. 207:1775. PubMed
常用抗体标记荧光染料的选择 随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列 (Life technology, USA); DyLight系列;Cy系列; IR Dye系列等等。使用最多的为AlexaFluor®系列和CFTM系列。CFTM系列染料的核心对比AlexaFluor®系列具有以下几点优势：1. 新型罗丹明核心罗丹明染料以优异
技术原理与方法｜超级色差校正物镜 PLAPON60XOSC 在脑组织四重免疫荧光分析中的应用
种类型的荧光抗体在单个标本中准确展示荧光标记分子的共定位情况。 PLAPON60XOSC 和 UPLSAPO60XO 的性能比较 2. 超级色差校正物镜的应用-脑组织的四重免疫荧光 图 1. 脑组织的四重免疫荧光。 VIAAT 染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VGluT3 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 大麻素合成酶 DGLα（白色）和大麻素受体 CB1（绿色）聚集在小鼠
红外荧光染料。 以花青素为基础的远红外荧光染料CF 647 比Cy 5、Alexa Fluor 647 明亮。 CF 660、Alexa Fluor® 660, Allophycocyanin (APC)等介于远红外近红外之间的荧光染料。 6、近红外（680-790nm处激发） CF 680R/ 680、Alexa Fluor 680, Cy 5.5, IR Dye 680等近红外荧光染料。 CF680 是高水溶性的以花青素为基础的染料，分子量大约为3000。该染料标记抗体极佳，发出
