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- ICFC
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
FOXP3
- 级别：
mouse/rat/human FOXP3 Antibody
- 目录编号：
mouse/rat/human FOXP3 Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
mouse/rat/human FOXP3 Antibody
- 抗体英文名：
Alexa Fluor® 647 anti-mouse/rat/human FOXP3 Antibody
- 抗体名：
FOXP3 Antibody
- 标记物：
mouse/rat/human FOXP3 Antibody
- 宿主：
小鼠
- 适应物种：
人、小鼠、大鼠
- 免疫原：
mouse/rat/human FOXP3 Antibody
- 亚型：
mouse/rat/human FOXP3 Antibody
- 形态：
mouse/rat/human FOXP3 Antibody
- 应用范围：
ICFC
- 保存条件：
2-8℃
- 浓度：
mouse/rat/human FOXP3 Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3200.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥6300.0 |
Description FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin,JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of Tregulatory cells than most cell surface markers (such as CD4 and CD25). Transducedexpression of FOXP3 in CD4 /CD25 cells has been shown to induce GITR, CD103, andCTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunityallergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice.
Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggestingthat this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse,two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical fulllength sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reactswith human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded byexon 2.
Verified Reactivity ：Human, Mouse, Rat
Reported Reactivity ：Cynomolgus, Rhesus, Baboon
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Full-length FOXP3 protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation ：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling ：The FOXP3 antibody solution should be stored undiluted between 2°C and 8°C, and protectedfrom prolonged exposure to light. Do not freeze.
Application ：ICFC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by intracellular flow cytometry using our TrueNuclear™ Transcription Factor Staining Protocol. For flow cytometric staining, the suggested useof this reagent is 5 µl per 10 cells in 100 µl volume. It is recommended that the reagent be titratedfor optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Excitation Laser ：Red Laser (633 nm)
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文献和实验1. Roncador G, et al. 2005 Eur. J. Immunol. 35:1681.
2. Mayack. S,et al. 2006. J. Immunol.176:2059. J. Immunol
3. Yang ZZ, et al. 2006. Blood 107:3639.
4. Gavin MA, et al. 2006. P. Natl. Acad. Sci. USA 103:6659.
5. Groh V, et al. 2006. Nature Immunology 7:755.
6. Lewkowicz P, et al. 2006 J. Immunol. 177:7155.
7. Luke PPW, et al. 2006. Amer. J. Transplant. 6(9):2023.
8. Bamias G, et al. 2007. J. Immunol. 178:1809.
9. Valencia X, et al. 2007. J. Immunol. 178:2579.PubMed
10. Davidson TS, et al. 2007. J. Immunol. 178:4022.
11. MacDonald K PA, et al. 2007. Blood doi:10.1182/blood-2007-01-067249.
12. Jaffar Z, et al. 2007. J. Immunol. 179:6193.
13. Müller M, et al. 2007. J. Immunol. 179:2774.
14. Jordan JM,et al. 2008.Infect Human. 76:3717. PubMed
15. Golovina TN,et al. 2008. J. Immunol. 181:2855. PubMed
16. Fallarino F, et al. 2009. J. Exp Med. 206:2511. PubMed
17. Banham Alison, et al. 2009. Vet Immunol and Immunop 127.3-4:376-381
18. Klunker S, et al. 2009. J. Exp Med. PubMed
19. Haque A, et al. 2010. J. Immunol. 184:2583. PubMed
20. Liu Y, et al. 2012. Food Chem Toxicol. 50:1920. PubMed
Product Citations：
1. Li S, et al. 2014. Virus Res. 180:84. PubMed
2. Palacios-Arreola M, et al. 2017. Sci Rep. 10.1038/s41598-017-10135-1. PubMed
3. Jayachandran R, et al. 2019. Immunity. 50:152. PubMed
4. Gao R, et al. 2021. iScience. 24:103133. PubMed
5. Chan JA, et al. 2022. Nat Commun. 13:4159. PubMed
6. Li Q, et al. 2022. Cell Rep. 40:111308. PubMed
7. Hoang TN, et al. 2021. Cell. 184:460. PubMed
8. Haque A, et al. 2010. J Immunol. 184:2583. PubMed
9. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
10. Kuwahara M, et al. 2014. Nat Commun. 5:3555. PubMed
11. Di Blasi D, et al. 2019. Cell Mol Gastroenterol Hepatol. 0.510416667. PubMed
12. Aqel SI, et al. 2021. JCI Insight. 6:e142376. PubMed
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