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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
999
- 靶点:
FGF-19
- 级别:
FGF-19 Antibody
- 目录编号:
FGF-19 Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
FGF-19 Antibody
- 抗体英文名:
Purified anti-FGF-19 Antibody
- 抗体名:
FGF-19 Antibody
- 标记物:
FGF-19 Antibody
- 宿主:
小鼠
- 适应物种:
人
- 免疫原:
FGF-19 Antibody
- 亚型:
FGF-19 Antibody
- 形态:
FGF-19 Antibody
- 应用范围:
WB
- 保存条件:
2-8℃
- 浓度:
0.5 mg/ml
- 规格:
100 µg
Description :FGF-19 belongs to a subfamily of the fibroblast growth factors (FGFs) called endocrine FGFs,which consists of FGF-19, FGF-21, and FGF-23. Unlike other subfamily of FGFs, FGF-19 hasa low binding affinity to heparin sulfate and functions as a circulating hormone with effects ondistant tissues. FGF-19 has reduced binding affinity to the FGF receptors and the interactionrequires two necessary cofactors that are α-Klotho and β-Klotho. In the ileum, FGF-19expression is initiated by bile acids-induced activation of farnesoid X receptor (FXR). Inresponse to bile acid stimulation, FGF-19 is secreted and enters the portal venous circulation,which subsequently down-regulates hepatic bile acid synthesis through repression of theCYP7A1 gene encoding cholesterol 7-alpha-monooxygenase. The impaired regulation of bileacids by FGF-19 leads to bile acid diarrhea also known as idiopathic bile acid malabsorption.FGF-19 has also been demonstrated to regulate carbohydrate and lipid metabolism.
Verified Reactivity :Human
Antibody Type :Monoclonal
Host Species :Mouse
Immunogen :Partial human FGF-19 recombinant protein (25-216 a.a.) expressed in E. coli.
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation :The antibody was purified by affinity chromatography.
Concentration :0.5 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :WB - Quality tested
Recommended Usage :Each lot of this antibody is quality control tested by Western blotting. For Western blotting, thesuggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titratedfor optimal performance for each application.
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