抗 Th-POK (ZFP-67) 荧光标记PE 抗体

anti-Th-POK (ZFP-67) Antibody-PE详细如下：

Description ：Th-POK is a member of the BTB-POZ domain-containing zinc finger transcription factor family.It regulates gene expression during intrathymic T cell differentiation. A single autosomalrecessive mutation of the Th-POK gene results in the absence of mature CD4+ helper T cells,called helper-deficient (HD) phenotype. In Th-POK deficient mice, MHC class II restrictedthymocytes are redirected to the CD8+ T cell lineage. On the contrary, forced expression ofTh-POK redirects MHC class I restricted thymocytes to the CD4+ T cell lineage. Inactivation ofTh-POK in mature CD4+ T cells results in induction of the genes preferentially expressed inCD8+ T cells, such as CD8, granzyme B, and IFN-γ. These findings suggest that Th-POK isessential in promoting commitment of immature T cells to the CD4 lineage and maintaining thecharacteristics of mature CD4+ T helper cells.

Verified Reactivity ：Human

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Partial human Th-POK recombinant protein (197-345 a.a.)

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation ：The antibody was purified by affinity chromatography and conjugated with PE under optimalconditions.

Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：ICFC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by intracellular immunofluorescent staining usingour nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagentis 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser ：Blue Laser (488 nm)、Green Laser (532 nm)、Yellow-Green Laser (561 nm)