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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
CD223
- 级别：
CD223 (LAG-3) Antibody
- 目录编号：
CD223 (LAG-3) Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
CD223 (LAG-3) Antibody
- 抗体英文名：
Brilliant Violet 711™ anti-human CD223 (LAG-3) Antibody
- 抗体名：
CD223 (LAG-3) 抗体
- 标记物：
CD223 (LAG-3) Antibody
- 宿主：
小鼠
- 适应物种：
人
- 免疫原：
CD223 (LAG-3) Antibody
- 亚型：
CD223 (LAG-3) Antibody
- 形态：
CD223 (LAG-3) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
CD223 (LAG-3) Antibody
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥3900.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥7500.0 |
Brilliant Violet 711™ anti-human CD223 (LAG-3) Antibody详细如下：
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation ：The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm isrecommended for detection, although filter optimization may be required depending on otherfluorophores used. Be sure to verify that your cytometer configuration and software setup areappropriate for detecting this channel. Refer to your instrument manual or manufacturer forsupport. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.
Excitation Laser ：Violet Laser (405 nm)
Description ：CD223, also known as LAG-3, is a 70 kD type I transmembrane glycoprotein that is involved inT-cell signaling. Similar to CD4, CD223 binds MHC class II, but with a higher affinity. CD223negatively regulates T-cell activation. It is expressed by activated T-cells and natural killer cells(NKs), as well as regulatory T-cells. It is transiently expressed on the surface of activated Tcells in acute conditions but high expression is maintained under tolerizing conditions. CD223deficiency results in reduced tumor growth. CD223 and PD-1 can act in synergy and reverseexhausted phenotypes, improve tumor rejection, and control viral load.
Verified Reactivity ：Human
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Human LAG-3 transfected cells.
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation ：The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™under optimal conditions.
Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤ 5 µl per million cells in100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm isrecommended for detection, although filter optimization may be required depending on otherfluorophores used. Be sure to verify that your cytometer configuration and software setup areappropriate for detecting this channel. Refer to your instrument manual or manufacturer forsupport. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.
Excitation Laser ：Violet Laser (405 nm)
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文献和实验该产品被引用文献
Product Citations ：
1. Myers JA, et al. 2022. JCI Insight. :. PubMed
2. Carnevale J, et al. 2022. Nature. 609:174. PubMed
3. Evgin L, et al. 2020. Nat Commun. 2.671527778. PubMed
1. Myers JA, et al. 2022. JCI Insight. :. PubMed
2. Carnevale J, et al. 2022. Nature. 609:174. PubMed
3. Evgin L, et al. 2020. Nat Commun. 2.671527778. PubMed
文献支持
Brilliant Violet 711™ 抗人 CD223 (LAG-3) 抗体
￥3900 - 7500
